Contemporary early left ventricular thrombus resolution by echocardiography: insight from a longitudinal multicenter registry

Abstract Funding Acknowledgements Type of funding sources: None. Background Multicenter longitudinal data are lacking regarding the incidence and time needed for total left ventricular thrombus (LVT) regression obtained with contemporary antithrombotic regimens diagnosed modern echocardiographic technology. Purpose To quantify effect therapy on LVT evolution using sequential up-to-date echocardiography in a large cohort patients LVT. Methods Ten centers were involved this observational prospective multicenter study. was defined as an echo-dense mass adjacent to hypokinetic or akinetic myocardial segment. be distinguishable from underlying myocardium, clear thrombus–blood interface required had visible at least 2 views during cardiac cycle. Initial follow-up echocardiograph scheduled 14±7 days (T0) 42±7 (T1). The early resolution when no longer detected T1. use different anticoagulant ultrasound contrast discretion attending physicians, according good clinical practice. Results From October 2020 November 2022, 99 (mean age 66 ± 11 years, 80% men) identified echocardiography, 53% used. Early observed 42%. Echocardiographic characteristics by shown Table. independent correlates smaller baseline area, higher LVEF, mobile (p<0.05). Conclusions In well-characterized present-day LVT, achieved less than half mostly related size heart function rather treatment despite high proportion therapy. next step will assess impact persistence subsequent outcomes.